GLP-1 Medications: Complete Comparison
An evidence-based comparison of Semaglutide, Tirzepatide, and Liraglutide to help you understand which medication might be right for your weight loss journey.
Semaglutide
GLP-1 Receptor Agonist
Tirzepatide
Dual GIP/GLP-1 Receptor Agonist
Liraglutide
GLP-1 Receptor Agonist
Side-by-Side Comparison
| Feature | Semaglutide | Tirzepatide | Liraglutide |
|---|---|---|---|
| Average Weight Loss | 15% | 21% | 8% |
| Dosing Frequency | Weekly | Weekly | Daily |
| Oral Option | Yes | No | No |
| Mechanism | GLP-1 | GIP + GLP-1 | GLP-1 |
| FDA Obesity Approval | Yes | Yes | Yes |
| A1C Reduction | 1.5-2% | 2-2.5% | 1-1.5% |
| Cardiovascular Data | Strong | Emerging | Moderate |
| Time on Market | 2017+ | 2022+ | 2010+ |
Pros & Cons
Pros
- Extensive clinical trial data
- Oral option available (Rybelsus)
- Well-established safety profile
- More widely available
- More insurance coverage
Cons
- Less weight loss than Tirzepatide
- GI side effects common
- Weekly injections required
- Expensive without insurance
Compounded vs Brand Name
Brand Name Medications
- • FDA approved with extensive safety data
- • Consistent quality and potency
- • May be covered by insurance
- • Higher cost ($900-1,500/month)
- • Subject to shortages
Compounded Medications
- • Made by 503A or 503B pharmacies
- • Significantly lower cost ($150-400/month)
- • Available during brand shortages
- • Quality varies by pharmacy
- • Not FDA approved (pharmacy regulated)
Important: Compounded medications are only legal when brand-name versions are on the FDA shortage list. Always ensure your compounding pharmacy is properly licensed and uses quality testing.
Which Should You Choose?
Choose Semaglutide if...
• You prefer an oral option (Rybelsus)
• Insurance coverage is important to you
• You want the most established safety data
• You have cardiovascular risk factors
Choose Tirzepatide if...
• Maximum weight loss is your priority
• You have type 2 diabetes
• You can pay out-of-pocket if needed
• You want the newest, most potent option
Choose Liraglutide if...
• You're an adolescent (12-17)
• You prefer daily over weekly injections
• You want the longest safety track record
• Other options aren't available
Pricing Comparison
Brand Name Medications
FDA-approved with consistent quality
Compounded Medications
Lower cost alternative during shortages
Pricing Note: Costs vary significantly based on dose, insurance coverage, manufacturer discounts, and pharmacy. Many brand manufacturers offer savings programs that can reduce costs. Compounded medications are only available when brand-name versions are on the FDA shortage list.
Where to Get GLP-1 Medications
These telehealth platforms offer GLP-1 medications with online consultations and home delivery.
Comprehensive program with brand-name and compounded options
Telehealth platform with compounded semaglutide
Personalized weight care with coaching included
Year-long metabolic health program
Affordable compounded options with direct shipping
Insurance-focused with dietitian support
Disclosure: We may receive compensation from providers listed above. This doesn't affect our recommendations. Always verify current pricing, availability, and consult with a healthcare provider before starting any medication.
Ready to Start Treatment?
Learn about proper dosing protocols or compare all available providers in detail.