The Complete Guide to GLP-1 Medications
Everything you need to know about semaglutide, tirzepatide, and other weight loss medications. Evidence-based information to help you make informed decisions about your health.
Explore the Guide
Body Recomposition
Retain muscle and strength while losing fat—medication optional
Medication Comparison
Compare Semaglutide, Tirzepatide, and other GLP-1 options
Dosing Guide
Titration schedules, injection techniques, and timing
Side Effects
Management strategies and when to seek help
Lab Work Guide
Essential tests and monitoring during treatment
Lifestyle & Nutrition
Optimize results with proper nutrition and exercise
Find a Provider
Telemedicine clinics and cost comparison
Savings & Discounts
Coupons, insurance tips, and cost-saving strategies
What Are GLP-1 Medications?
GLP-1 (glucagon-like peptide-1) receptor agonists are a class of medications originally developed for type 2 diabetes that have shown remarkable effectiveness for weight loss. They work by mimicking a natural hormone that regulates appetite, blood sugar, and digestion.
When you eat, your body naturally releases GLP-1, which signals to your brain that you're full. These medications amplify that signal, leading to reduced appetite, slower gastric emptying, and ultimately significant weight loss.
The two main medications in this class are Semaglutide (brand names: Ozempic, Wegovy, Rybelsus) and Tirzepatide (brand names: Mounjaro, Zepbound). Tirzepatide is a dual GIP/GLP-1 agonist, targeting two hormones for potentially greater effects.
How Do They Work?
- Appetite Suppression: Signals satiety to the brain, reducing hunger and food cravings
- Slower Digestion: Delays gastric emptying, keeping you fuller longer after meals
- Blood Sugar Control: Stimulates insulin release and reduces glucagon in response to meals
- Reduced "Food Noise": Many users report decreased obsessive thoughts about food
Key Benefits
Significant Weight Loss
15-25% body weight reduction with consistent use
Cardiovascular Benefits
Reduced risk of heart attack and stroke
Metabolic Improvements
Better blood sugar control and insulin sensitivity
Reduced Appetite
Natural hunger suppression and food noise reduction
Who Is a Candidate?
GLP-1 medications are FDA-approved for specific patient populations. While they've shown remarkable results, they're not appropriate for everyone. Here are the typical criteria for candidacy:
- BMI of 30 or higher (obesity)
- BMI of 27+ with weight-related conditions (diabetes, hypertension, sleep apnea)
- Previous unsuccessful attempts at diet and exercise alone
- No personal or family history of medullary thyroid carcinoma
- No history of pancreatitis or severe GI conditions
- Not pregnant, breastfeeding, or planning pregnancy
Expected Results
*Results from clinical trials at maximum doses with diet and exercise
Cost Overview
| Medication | Brand (Cash) | Compounded | With Insurance |
|---|---|---|---|
| Wegovy (Semaglutide) | $1,350/mo | $150-300/mo | $25-150/mo |
| Zepbound (Tirzepatide) | $1,060/mo | $200-400/mo | $25-150/mo |
| Ozempic (Semaglutide) | $970/mo | $150-300/mo | $25-100/mo |
| Mounjaro (Tirzepatide) | $1,070/mo | $200-400/mo | $25-150/mo |
Popular Providers
Ro
Comprehensive program with GLP-1 access and metabolic health focus
From $145/moHims/Hers
Compounded semaglutide with personalized treatment plans
From $199/moFound
Science-backed weight care with multiple medication options
From $99/moCalibrate
Metabolic health program with coaching and medication
From $135/moFrequently Asked Questions
Ready to Get Started?
Compare medications to find the right fit, learn about proper dosing, or connect with a licensed provider who can evaluate your candidacy.