GLP-1 Dosing & Injection Guide
Master the art of proper GLP-1 administration. From titration schedules to injection technique, everything you need to know for safe and effective treatment.
Titration Schedules
Titration is the process of gradually increasing your dose to minimize side effects while reaching therapeutic levels. Never skip titration steps unless directed by your provider.
| Timeline | Dose | Purpose | Notes |
|---|---|---|---|
| Weeks 1-4 | 0.25mg | Initial tolerance | Start low to minimize GI side effects |
| Weeks 5-8 | 0.5mg | Building up | First therapeutic dose level |
| Weeks 9-12 | 1.0mg | Therapeutic | Many see significant results here |
| Weeks 13-16 | 1.7mg | Enhanced | Increased appetite suppression |
| Week 17+ | 2.4mg | Maximum | Maintenance dose for Wegovy |
Injection Sites
Abdomen
2 inches from navel, avoid waistline
Front of Thighs
Middle third, alternate legs
Back of Upper Arms
May need assistance
Site Rotation: Rotate injection sites weekly to prevent lipodystrophy (fatty tissue changes). Keep at least 1 inch between injection sites in the same area.
Step-by-Step Injection Technique
Wash hands thoroughly with soap and water
Check medication for particles or discoloration
Select injection site and clean with alcohol swab
Let alcohol dry completely (30 seconds)
Pinch skin gently to create a fold
Insert needle at 90-degree angle (or 45° if thin)
Press plunger slowly and steadily
Hold for 5-10 seconds after injection
Remove needle and apply gentle pressure
Dispose of needle in sharps container
Timing Recommendations
When to Inject
• Choose the same day each week for consistency
• Any time of day works (morning or evening)
• Can be taken with or without food
• Some prefer evenings to sleep through initial side effects
• Set a weekly reminder on your phone
If You Miss a Dose
Within 5 days: Take the dose as soon as you remember, then continue with your regular schedule.
More than 5 days: Skip the missed dose and take the next dose on your regular day.
Never: Take two doses to make up for a missed dose.
Storage Requirements
Before First Use
Store in refrigerator at 36°F to 46°F (2°C to 8°C)
Do not freeze. Do not use if frozen.
After First Use
Can be stored at room temperature (up to 86°F/30°C) or refrigerated
Use within 56 days (8 weeks)
Protect From
Direct sunlight and heat sources
Keep cap on when not in use
Pen vs Vial: Which Format?
Pre-Filled Pens (Brand)
- Pre-measured doses, no drawing up
- Easier for beginners
- More portable
- Less room for error
Vials (Compounded)
- Significantly lower cost
- Flexible dosing options
- Requires drawing up medication
- Need to purchase syringes separately
Important Tips
- • Never share pens or needles with others
- • Use a new needle for each injection
- • Don't inject into areas with scars or stretch marks
- • Let refrigerated medication warm to room temp before injecting
- • Stay hydrated, especially during initial titration
- • Report any unusual reactions to your provider
How to Purchase GLP-1 Medications
GLP-1 medications require a prescription. These telehealth platforms offer online consultations, prescriptions (if eligible), and home delivery. Costs and availability vary by location and insurance.
Ro
Comprehensive GLP-1 program with medical oversight and ongoing support
Hims
Telehealth platform offering weight loss medications with provider support
Medications
Features
- Online consultations
- Monthly subscriptions
- Pharmacy network
Found
Personalized weight care program combining medication with coaching
Medications
Features
- Personalized plans
- Health coaching
- Community support
Calibrate
Year-long metabolic health program with GLP-1 medication access
Henry Meds
Affordable compounded semaglutide with personalized dosing
Medications
Features
- Lower cost
- Flexible dosing
- Direct shipping
Sequence
Comprehensive weight management with lifestyle and medication support
Medications
Features
- Insurance support
- Dietitian access
- Long-term focus
Disclaimer: We may receive compensation from some providers listed above. This does not influence our recommendations, which are based on research and user feedback.
Always verify pricing, insurance coverage, and medication availability directly with each provider. Eligibility for GLP-1 medications is determined by licensed healthcare providers.
Need Help Managing Side Effects?
Learn about common side effects and proven strategies to manage them during your titration journey.