MOTS-C
The Mitochondrial Exercise Mimetic
A mitochondrial-derived peptide that activates AMPK and mimics many benefits of exercise, enhancing metabolic health and longevity.
Research Compound
About MOTS-C
MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA Type-C) is a recently discovered mitochondrial-derived peptide that has revolutionized our understanding of how mitochondria communicate with the rest of the body. Often called an 'exercise mimetic,' MOTS-C activates AMPK and promotes metabolic flexibility, glucose uptake, and fatty acid oxidation—effects similar to those produced by exercise. Natural MOTS-C levels decline with age, and supplementation may help restore youthful metabolic function and enhance physical performance.
Mechanism of Action
MOTS-C is encoded in the mitochondrial genome and secreted into the bloodstream where it acts as a signaling molecule. It activates AMPK (the master metabolic regulator), increases glucose uptake in muscle tissue, enhances fatty acid oxidation, and improves insulin sensitivity. MOTS-C also activates the folate-methionine cycle, influencing cellular metabolism and stress resistance at the epigenetic level.
How MOTS-C Works in Your Body:
- Target Receptors: MOTS-C binds to specific receptors that trigger downstream signaling cascades related to its primary benefits.
- Physiological Response: The body responds by modulating natural processes—whether hormone release, tissue repair, or cellular signaling—without replacing endogenous function.
- Timeline: Effects typically begin within 1-2 weeks, with optimal results seen over the recommended protocol duration.
Dosing Protocol
Frequency
3-5 times per week
Timing
Morning, ideally before exercise
Duration
4-8 week cycles
Important Notes
5-10mg per dose via subcutaneous injection. Some protocols use higher doses (15-20mg) for obesity or metabolic dysfunction. May enhance exercise performance when taken pre-workout.
Clinical Research
3 studies on MOTS-C
Metabolic Regulation Study
MOTS-C improved glucose regulation and insulin sensitivity in diet-induced obese mice.
Cell Metabolism
Exercise Enhancement
MOTS-C treatment improved exercise capacity and metabolic adaptations to physical training.
Nature Communications
Aging and MOTS-C Levels
Circulating MOTS-C levels decline with age and are associated with metabolic dysfunction.
Aging Cell
Important Safety Information
Medical Disclaimer: The information provided about MOTS-C is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before starting any new supplement or peptide protocol.
Research Status: While MOTS-C has shown promising results in research studies, many peptides are still being studied and may not be approved by regulatory bodies like the FDA for specific uses. The research cited represents ongoing scientific investigation.
Individual Variation: Responses to peptides vary significantly between individuals. What works for one person may not work for another. Side effects, while generally mild, can occur and should be monitored closely.
Quality & Sourcing: If you choose to use peptides, ensure you obtain them from reputable, tested sources. Peptide quality, purity, and proper storage are critical for safety and efficacy.
Legal Considerations: Peptide regulations vary by country and jurisdiction. Some peptides may require a prescription or may have restrictions on their use. Research the laws in your area before obtaining or using peptides.