HCG (Human Chorionic Gonadotropin)
Maintain Fertility & Testicular Function on TRT
A hormone that mimics LH to preserve testicular size, function, and fertility during testosterone replacement therapy.
Prescription Required
Can't get HCG (Human Chorionic Gonadotropin) through your GP? These telemedicine providers specialize in peptide therapy.
Everlywell
FDA-approved tesamorelin and comprehensive peptide therapy with at-home testing.
Hone Health
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Marek Health
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Everlife.md
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Peter MD
Telemedicine platform specializing in peptide therapy and hormone optimization.
Defy Medical
Established telemedicine clinic offering peptides, HRT, and regenerative therapies.
Always consult with a licensed physician before starting any peptide therapy.
About HCG (Human Chorionic Gonadotropin)
Human Chorionic Gonadotropin (HCG) is a hormone naturally produced during pregnancy but used therapeutically in men to stimulate testosterone production from the testes. When on TRT, the body's natural LH production shuts down, leading to testicular atrophy and infertility. HCG mimics LH, keeping the testes active and producing their own testosterone and sperm. It's an essential component of comprehensive TRT protocols for men who want to preserve fertility or maintain testicular size and function.
Mechanism of Action
HCG binds to the same receptors as luteinizing hormone (LH) in the Leydig cells of the testes, stimulating them to produce testosterone. This maintains intratesticular testosterone levels necessary for sperm production, even when the pituitary has stopped producing natural LH due to exogenous testosterone. By keeping the testes active, HCG prevents atrophy and maintains the pathway for natural testosterone production if TRT is discontinued.
How HCG (Human Chorionic Gonadotropin) Works in Your Body:
- Target Receptors: HCG (Human Chorionic Gonadotropin) binds to specific receptors that trigger downstream signaling cascades related to its primary benefits.
- Physiological Response: The body responds by modulating natural processes—whether hormone release, tissue repair, or cellular signaling—without replacing endogenous function.
- Timeline: Effects typically begin within a few days, with optimal results seen over the recommended protocol duration.
Dosing Protocol
Frequency
2-3 times weekly
Timing
Consistent days, often with TRT injection schedule
Duration
Ongoing while on TRT
Important Notes
250-500 IU per injection, 2-3x weekly. Higher doses (1000-2000 IU) for fertility protocols. Subcutaneous injection. Monitor estradiol as HCG can increase aromatization. Some use only during TRT 'cruise' phases.
Clinical Research
3 studies on HCG (Human Chorionic Gonadotropin)
Fertility Preservation
HCG co-administration maintained spermatogenesis in 94% of men on TRT who wished to preserve fertility.
The Journal of Urology
Intratesticular Testosterone
HCG maintained intratesticular testosterone at 25% of baseline vs near-zero without HCG during TRT.
Journal of Clinical Endocrinology & Metabolism
Testicular Volume
HCG prevented the testicular volume reduction typically seen with TRT monotherapy.
Fertility and Sterility
Important Safety Information
Medical Disclaimer: The information provided about HCG (Human Chorionic Gonadotropin) is for educational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider before starting any new supplement or peptide protocol.
Research Status: While HCG (Human Chorionic Gonadotropin) has shown promising results in research studies, many peptides are still being studied and may not be approved by regulatory bodies like the FDA for specific uses. The research cited represents ongoing scientific investigation.
Individual Variation: Responses to peptides vary significantly between individuals. What works for one person may not work for another. Side effects, while generally mild, can occur and should be monitored closely.
Quality & Sourcing: If you choose to use peptides, ensure you obtain them from reputable, tested sources. Peptide quality, purity, and proper storage are critical for safety and efficacy.
Legal Considerations: Peptide regulations vary by country and jurisdiction. Some peptides may require a prescription or may have restrictions on their use. Research the laws in your area before obtaining or using peptides.